Morphological studies of the endomorphinergic
neurons in the central nervous system
by
Wang QP, Zadina JE, Guan JL, Shioda S.
Department of Anatomy,
Showa University School of Medicine, Tokyo, Japan.
Jpn J Pharmacol 2002 Jul;89(3):209-15

ABSTRACT

Endomorphins (EMs) are newly found endogenous opioid peptides. Both endomorphin-1 (EM-1) and -2 (EM-2) are composed of four amino acids. Their high affinity and specificity for mu-opioid receptors have been confirmed by many physiological and pharmacological studies. In the present minireview, we discuss the distribution and localization of these peptides. While EM-2 is more prevalent in the spinal cord and lower brainstem, EM-1 is more widely and densely distributed throughout the brain than EM-2. We also discuss the possible coexistence of EM with other neurotransmitters. Finally, we introduce some new results regarding the ultrastructure and synaptic relationships of EM-2 obtained by the immunoelectron microscopic method.

Pain
Knockout mice
Endomorphins 1 and 2
Endomorphins and the mouse
The rewards of endomorphin 1
Endomorphins and the mu-opioid receptor
Endomorphins and related opioid peptides
Endomorphin 1, dopamine and nitric oxide
Rewarding and psychomotor stimulant effects of endomorphin 1
Endomorphin-1, accumbal dopamine and the mu-opioid receptor

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