Effect of opioid antagonism on conditioned
place preferences to snack foods
by
Jarosz PA, Sekhon P, Coscina DV.
College of Nursing, Wayne State University,
5557 Cass Avenue, Detroit, MI, 48202, USA.
Pharmacol Biochem Behav. 2006 Mar 13;
ABSTRACTPrevious research has shown that food-deprived rats acquire conditioned place preferences (CPPs) to sweet liquids that are largely attenuated by the opioid antagonist naltrexone (NAL). This study determined if ad libitum Chow-fed rats can learn CPPs when given relatively brief exposures to different solid snack foods (SFs)-one high in sugar (Froot Loops cereal: FL(R)) vs. one high in fat (Cheetos(R): C). Two groups of 16 male rats were trained during 20-min sessions to eat either FL or C in one side of a three-chambered CPP apparatus vs. Chow in the opposite side on alternating days for 20 days. Rats ate considerably more SFs of both types than Chow during the conditioning sessions (SFs: about 23kcal versus Chow: about 7kcal). Ten-minute tests for CPPs in the absence of SFs showed that the time spent on SF-conditioned sides increased significantly compared to pre-conditioning tests. Analyses of variance for re-tested CCPs after 0.1, 1.0, 2.5, and 5.0mg/kg NAL showed dose-dependent suppressions of CPPs to both SFs. These data show that consuming sweet or fatty SFs can become reliably associated with environmental cues in the non-deprived state. The endogenous opioid system, which mediates hedonic aspects of palatable food intake, appears to mediate these learned associations.Mu
Delta
Feeding
Fentanyl
Tramadol
Tolerance
Naltrexone
Endomorphins
Buprenorphine
Opioids and depression
Opioid receptor migration
Depression, opioids and the HPA
and further reading
Refs
HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
