Transdermal therapeutic fentanyl-system (TTS-F)
by
Mystakidou K, Katsouda E, Tsilika E, Parpa E, Vlahos L.
Department of Radiology,
University of Athens, School of Medicine,
Korinthias 27, Athens 115 26, Greece.
mistakidou@yahoo.com
In Vivo. 2004 Sep-Oct;18(5):633-42

ABSTRACT

Fentanyl, a surgical analgesic and general anaesthetic, is a lipophilic short-acting synthetic opioid, having a selective potent effect on mu receptors. The transdermal therapeutic fentanyl-system (TTS-F) allows for a continued and sustained titratable amount of fentanyl to be delivered without the inconvenience of the typical 24-h administration of other analgesics. Although incidences of respiratory depression led to TTS-F being contraindicated for postoperative analgesia, it is currently undergoing Phase III trials for nociceptive, neuropathic and chronic moderate to severe pain in a variety of settings. It demonstrates a slow pharmacokinetic profile and incidences of breakthrough pain may still require rapid analgesia, for which intravenous and bolus administration of rapid acting opioids remain 'gold standard' However, TTS-F is finding uses for chronic pain of cancer origin where it offers a solution for step 3-pain (WHO) management on the WHO analgesic ladder. More recent data indicates that TTS-F is not only effective for neuropathic but also nociceptive non-cancer and cancer pain alike. This review presents an overview of the synthesis, delivery, pharmacokinetics, toxicity and clinical pharmacology of the transdermal delivery of fentanyl.

Pain
Morphine
Duragesic
Fentanyl for cats
Fentanyl analogs
4-methyl fentanyl
Fentanyl: structure
Driving on fentanyl
Fentanyl: synthesis
Fentanyl and ketamine
Opioids and anaesthesia
Fentanyl patches for dogs
Remifentanil and alfentanil
Fentanyl: subjective effects
Fentanyl versus remifentanil
Fentanyl and the immune system
Actiq ('perc-a-pop'): the fentanyl lollipop

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