Clinical evaluation of the analgesic
potency of lofentanil in postoperative pain
by
Van den Abeele G, Camu F
Acta Anaesthesiol Belg 1983; 34(1):41-7

ABSTRACT

The efficacy and safety of IM lofentanil, the most potent morphinomimetic drug available, for rapid control of postoperative pain was compared with IM piritramide and placebo in a study of 120 patients. Piritramide 7.5 mg and 15 mg, lofentanil 0.25 micrograms, 0.50 micrograms and 0.75 micrograms had a rapid onset of analgesic effect. Significant differences in pain intensity and pain relief when compared to placebo were observed at each observation period for each drug. Piritramide 15 mg is significantly more effective at 4, 5 and 6 hours when compared to lofentanil 0.75 micrograms, thus having a longer lasting effect than lofentanil 0.75 micrograms. There were no significant differences in pain relief between the different doses of lofentanil or between the different doses of piritramide. Side effects of very low incidence included nausea, vomiting and sedation in both piritramide and lofentanil groups.

Pain
Morphine
Fentanyl
Duragesic
Alfentanil
Sufentanil
Remifentanil
Endomorphins
Lofentanil : structure
Opioids and anaesthesia
Opioids, mood and cognition

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