Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration
by
Davis MP, Walsh D.
Harry R. Horvitz Center for Palliative Medicine,
Cleveland Clinic Foundation,
9500 Euclid Avenue, Cleveland, OH 44195, USA.
davism6@ccf.org
Support Care Cancer 2001 Mar; 9(2):73-83

ABSTRACT

Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions. Several guidelines of administration have been established. Physicians who are involved in pain management should have a fundamental understanding of methadone's unique properties.

Pain
LAAM
Arousal
Fentanyl
Tramadol
Tolerance
Endomorphins
OTC cough syrups
LAAM v methadone
Methadone: structure
Opioids and depression
Methadone and cocaine
Methadone maintenance
Rapid opioid detoxification
Methadone and cancer pain
Methadone: "killer drug" etc

Refs
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