Opioid receptors and acetaminophen (paracetamol)
by
Raffa RB, Walker EA, Sterious SN.
Department of Pharmaceutical Sciences,
Temple University School of Pharmacy,
3307 North Broad Street,
Philadelphia, PA 19140, USA.
Eur J Pharmacol. 2004 Oct 25;503(1-3):209-210

ABSTRACT

We report that the acetaminophen (paracetamol)-induced spinal (intrathecal, i.t.)/supraspinal (intracerebroventricular, i.c.v.) site/site antinociceptive 'self-synergy' in mice is attenuated by the opioid receptor subtype selective antagonists beta-funaltrexamine hydrochloride (beta-FNA; μ), naltrindole (delta), and nor-binaltorphine hydrochloride (nor-BNI; kappa). These findings further implicate endogenous opioids (viz., endorphins, enkephalins, and dynorphins) and their pathways as contributors to the central antinociceptive action of acetaminophen.

Babies
Manic cats
Opiated crickets
Morphine worms
Fentanyl and ketamine
Opioids, mood and cognition
Opioids, dopamine and alcohol
Chocolate and endogenous opioids
Acetaminophen (paracetamol), pain and dynorphin A

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family