Mu opioid receptor: a
gateway to drug addiction
by
Contet C, Kieffer BL, Befort K.
Institut de Genetique et de Biologie Moleculaire et Cellulaire,
CNRS/INSERM/ULP, UMR7104, Parc d'Innovation,
1 rue Laurent Fries BP 10142,
67404 Illkirch Cedex, Strasbourg, France.
Curr Opin Neurobiol. 2004 Jun;14(3):370-8
ABSTRACTMu opioid receptors mediate positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation, and our understanding of mu receptor function is central to the development of addiction therapies. Recent data obtained in native neurons confirm that mu receptor signaling and regulation are strongly agonist-dependent. Current functional mapping reveals morphine-activated neurons in the extended amygdala and early genomic approaches have identified novel mu receptor-associated proteins. A classification of about 30 genes either promoting or counteracting the addictive properties of morphine is proposed from the analysis of knockout mice data. The targeting of effectors or regulatory proteins, beyond the mu receptor itself, might provide valuable strategies to treat addictive disorders.Mu
SOD mu
Mu opioid receptor subtypes
Genes, pharmacology and mu
Depression, opioids and the HPA
Kappa upregulation and addiction
Mice without mu don't miss their moms
Chemical addiction and the science of love
Opioids, depression and learned helplessness
The mu-opioid receptor system and the physiological regulation of emotion
and further reading
Refs
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The Abolitionist Project
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The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
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To Healthy Mood Boosters For All The Family
