Patterns of response to acute naloxone
infusion in Tourette's syndrome
by
van Wattum PJ, Chappell PB,
Zelterman D, Scahill LD, Leckman JF
Child Study Center,
Department of Psychiatry,
Yale University School of Medicine,
New Haven, Connecticut, USA.
Mov Disord 2000 Nov; 15(6):1252-4

ABSTRACT

The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose-related effect of the opioid antagonist naloxone on tic behavior in patients with Tourette's syndrome (TS). Fifteen subjects with TS were challenged with randomized doses (30 and 300 microg/kg) of naloxone at 3-day intervals. Videotaped recordings of tic behavior were counted in a "blind" fashion. We found that naloxone had opposite effects on tics at different dosages. The low dose caused a significant decrease in tics, whereas the high dose caused a significant increase in tics. Therefore, activity at opioid receptors appears to influence the expression of TS, and the difference in response to naloxone in TS subjects may be based on a dose-response effect.

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