Obviation of opioid withdrawal syndrome by concomitant administration
of naltrexone in microgram doses: two psychonautic bioassays
by
Ott J.
Entheobotanica, Solothurn, Switzerland.
J Psychoactive Drugs. 2006 Mar;38(1):101-5.

ABSTRACT

Two psychonautic bioassays (self-experiments) in stepwise and abrupt cessation of long-term daily oral ingestion habits of 800 mg of codeine phosphate are presented. Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism. These experiments are analyzed in the context of a conjectured, rapid, iterative reduction and complete elimination of opioid tolerance, once acquired. It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.

Pain
CREB
G protein
Morphine
Tramadol
Sufentanil
Methadone
Oxycodone
Peroxynitrite
Endomorphins
Novelty and pain
Signalling mechanisms
Fentanyl and ketamine
The extended amygdala
Opioid receptor migration
Opioids, mood and cognition
Anxiety, opioids, cholecystokinin and tolerance
Low dose naltrexone reduces forebrain noradrenaline efflux in withdrawing morphine addicts

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